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| Product name: | AF/LE Purified Anti-Mouse CD103 Monoclonal Antibody |
| Catalog: | DL21006F |
| Synonyms : | Integrin alpha-E,Itgae,Integrin alpha M290,CD103 |
| Reactivity: | Mouse |
| Applications: | FCM,IHC,Block |
| Size: | 50 ug/500 ug/1 mg/ |
| Host: | Rat |
| Clonality: | |
| Background: | CD103 is a type I transmembrane glycoprotein known as ??E integrin or Integrin ??IEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-?? stimulation. In association with integrin ??7, CD103 is expressed as ??E/??7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 16407 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |