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| Product name: | AF/LE Purified Anti-Mouse CD274/PD-L1 Monoclonal Antibody |
| Catalog: | DL21654F |
| Synonyms : | B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 |
| Reactivity: | Mouse |
| Applications: | FCM,IHC,IF,Block |
| Size: | 50 ug/500 ug/1 mg/ |
| Host: | Rat |
| Clonality: | |
| Background: | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-?? activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-??, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 60533 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |