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| Product name: | AF/LE Purified Anti-Human CD28 Monoclonal Antibody |
| Catalog: | DL22135F |
| Synonyms : | PAS2,MNS,HGpMiX,GYPA,GPSAT |
| Reactivity: | Human |
| Applications: | Activ, FCM, IHC, IP |
| Size: | 50 ug/500 ug/1 mg/ |
| Host: | Mouse |
| Clonality: | |
| Background: | CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 940 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |