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| Product name: | Purified Anti-Human CD45 Monoclonal Antibody |
| Catalog: | DL20580F |
| Synonyms : | Receptor-type tyrosine-protein phosphatase C,Ptprc,L-CA,Ly-5,T200,CD45 |
| Reactivity: | Human |
| Applications: | FCM |
| Size: | 25 ug/100 ug |
| Host: | Mouse |
| Clonality: | |
| Background: | CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | PBS with 0.05% Proclin300 |
| Dilution: | |
| Gene ID(Human): | 5788 |
| Storage: | Store at 2~8℃. Do not freeze. |