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| Product name: | Anti-Human Notch3 Monoclonal Antibody(APC Conjugated) |
| Catalog: | DL21927F |
| Synonyms : | NOTCH3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain |
| Reactivity: | Human |
| Applications: | FCM |
| Size: | 20 Tests/50 Tests/100 Tests/200 Tests |
| Host: | Mouse |
| Clonality: | |
| Background: | The Notch receptors are highly conserved from invertebrates to mammals. While Notch 1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences. The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus. This translocation triggers a series of signaling processes. Notch 3 is primarily expressed in adult arterial smooth muscle cells. Notch3 gene mutation can cause CADASIL, a hereditary early stroke syndrome. |
| Concentration: | |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Dilution: | |
| Gene ID(Human): | 4854 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |