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| Product name: | AF/LE Purified Anti-Mouse CD279/PD-1 Monoclonal Antibody |
| Catalog: | DL21637F |
| Synonyms : | PD-1, Programmed Death-1 |
| Reactivity: | Mouse |
| Applications: | Block, Neut, FCM, WB, IHC, IF |
| Size: | 50 ug/500 ug/1 mg/ |
| Host: | Rat |
| Clonality: | |
| Background: | CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 18566 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |