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| Product name: | AF/LE Purified Anti-Human CD279/PD-1 Monoclonal Antibody |
| Catalog: | DL22249F |
| Synonyms : | PDCD1,PD1,Protein PD-1,hPD-1 |
| Reactivity: | Human |
| Applications: | FCM |
| Size: | 50 ug/500 ug/1 mg/ |
| Host: | Mouse |
| Clonality: | |
| Background: | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 um filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg ( < 0.002EU/ug) as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 3683 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |