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| Product name: | AF/LE Purified Anti-Human CD279/PD-1 Antibody |
| Catalog: | DL21621F |
| Synonyms : | PD-1, Programmed Death-1 |
| Reactivity: | Human |
| Applications: | Block,Neut,FCM |
| Size: | 50μg |
| Host: | Mouse |
| Clonality: | |
| Background: | Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. |
| Concentration: | 0.5 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
| Dilution: | |
| Gene ID(Human): | 5133 |
| Storage: | Store at 2~8°C. Do not freeze. |