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| Product name: | PE Anti-Mouse Foxp3 Antibody |
| Catalog: | DL22662F |
| Synonyms : | Forkhead box protein P3,IPEX,JM2,Foxp3 |
| Reactivity: | Mouse |
| Applications: | ICFCM |
| Size: | 20Tests |
| Host: | Mouse |
| Clonality: | |
| Background: | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. |
| Concentration: | |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Dilution: | |
| Gene ID(Human): | 50943,20371,317382 |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. |