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| Product name: | PE/TR Anti-Human CD47 Antibody |
| Catalog: | DL23062F |
| Synonyms : | Leukocyte surface antigen CD47,Cd47,Integrin-associated protein,IAP |
| Reactivity: | Human |
| Applications: | FCM |
| Size: | 20Tests |
| Host: | Mouse |
| Clonality: | |
| Background: | CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes. |
| Concentration: | |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Dilution: | |
| Gene ID(Human): | 961 |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. |