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| Product name: | Purified Anti-Human CD274/PD-L1 Monoclonal Antibody |
| Catalog: | DL21664F |
| Synonyms : | B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 |
| Reactivity: | Human |
| Applications: | FCM,IHC |
| Size: | 25 ug/100 ug |
| Host: | Mouse |
| Clonality: | |
| Background: | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-?? production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
| Concentration: | 0.2 mg/mL |
| Immunogen: | |
| Purification_Method: | |
| Buffer: | PBS with 0.05% Proclin300 |
| Dilution: | |
| Gene ID(Human): | 29126 |
| Storage: | Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze. |